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Gray Reference

Chronic exposure (approximately 40 months) to mixed molds in a water-damaged building.

  • Patients had a preponderance of neurological and immune-related conditions:

    • 100% with both CNS and peripheral nervous system complaints

    • Severe fatigue (75%)

    • Shortness of breath and chest tightness (75%)

    • Recurrent flu-like illness (61%)

    • Sensory neuropathy (43%)

    • Sensory motor polyneuropathy (30%)

    • Brain stem auditory evoked response (BAER) abnormalities (55%)

    • Optic nerve dysfunction (10%)

    • Abnormal EEG (10%)

    • Auto antibodies against neural antigens myelin basic protein (MBP), ganglioside GMI, and sulfatide

    • Increased C3 and C4 compliments and immune complexes IgG, IgM, and IgA compatible with inflammatory conditions

    • Increased T and B cell markers and increased helper/suppressor ratio, indicating a relative lymphocytosis and immune activation

    • Elevated mitogenesis to PHA, ConA, PWM, and LPS

    • Natural killer cell activity suppressed (42%)

  • Abnormally high levels of antinuclear antibodies, autoantibodies against smooth muscles, and CNS myelin antibodies were found, and odds ratios for each were significant at 95% confidence intervals, showing a dramatic increased risk for autoimmunity.

Common autoimmune diseases that can be associated with mycotoxicosis include:

    • Thyroiditis (Hashimoto's Disease or Grave's Disease)

    • Type I Diabetes

    • Rheumatoid Arthritis

    • Crohn's Disease and most Ulcerative Colitis

    • Lupus

    • Polymyositis or Dermatomyositis

    • Sjogren's Syndrome

    • Scleroderma

    • Psoriasis

    • Multiple Sclerosis

    • Myasthena Gravis

    • Narcolepsy

    • Guillain-Barre' Syndrome

  • The percentage of exposed individuals with increased lymphocyte phenotypes were: B cells CD20+ 76%, CD5+CD25+ 69%, CD3+CD26+ 91%, CD8+HLR- DR+ 62% and CD8+CD38+ 57%, whereas other phenotypes were decreased: CD8+CD1 1B+ 16% and CD3-16-CD56+ 39%. Mitogenesis to phytohemagglutinin was decreased in 26% of the exposed patients.

  • It is concluded that these patients with an ongoing exposure to molds had developed neurological dysfunction and pathology, while at the same time undergoing continuous antigenic stimulation resulting in the above immune findings.

Gray, et al. Mixed Mold Mycotoxicosis: Immunological changes in humans following exposure in water-damaged buildings. Arch Environ Health, 2003.

[This Mixed Mold Mycotoxicosis may exist independently of, or in addition to, the other severe fungal-derived pathologies --- Eosinophilic Fungal Rhinosinusitis and Fungal Exposure Endocrinopathy.]

Case History:

  • Patient presentation:

  • A 26-year-old female with toxic mold exposure from a leaking house trailer presented with left leg and arm paralysis, left eye blindness, partial blindness in right eye, catheter in paralyzed neurogenic bladder, and unable to walk or stand without assistance.

  • Treatment:

  • She did not reenter her home nor remove anything from the home. She washed the clothes she was wearing in antifungal detergent. She began on Sporonox 200 mg 2 times per day, saline nose washes, Amphotericin nose spray, 3 sprays 4 times per day, and Intramax vitamins with carbon. After 5 weeks, her arm, leg, and bladder paralysis resolved and her vision improved in the right eye with light perception in the left eye. The key was fungal antigen removal from the patient and removal of the patient from the moldy environment. For very sick patients, this is the only effective way to ensure a safe environment.